Our publications

The exclusivity and confidentiality of the projects that we perform for our clients generally do not allow us to publish about the results. There are a few exceptions, however, where our work has led to joint publications and patent applications.

Patents:

• HIV Replication Inhibitors.
  US 2003 0171374
• Processes for the Preparation of 4-[[4-[[4-(2-Cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile.
  WO 2004 016581
• HIV Inhibiting 1,2,4-Triazines.
  WO 2004 074266
• Substituierte 3-Pyrrolidin-indol Derivate.
  WO 2005 019208
• HIV Replication Inhibiting Purine Derivatives.
  WO 2005 028479
• Preparation of Biaryls.
  WO 2009 003650
• Isothiazole and Pyrazole Derivatives as Fungicides.
  WO 2009 007098

Papers:

• A New Allosteric Site in Glycogen Phosphorylase B as a Target for Drug Interactions.
  Structure, 2000, 8, 575–584.
• Water-Soluble and “Self-Assembled” Polyoxometalate as a Recyclable Catalyst for Oxidation of Alcohols in Water with Hydrogen Peroxide.
  J. Am. Chem. Soc. 2003, 125, 5280-5281.
• Inhibition of Fatty Acid Synthase Prevents Preadipocyte Differentiation.
  Biochem. Biophys. Res. Comm. 2005, 328, 1073–1082.
• Disproportionation of Hydrogen Peroxide into Singlet Oxygen Catalyzed by Lanthanum-exchanged Zeolites.
  J. Catalysis, 2005, 233, 422–433.
• Bioisosteric Replacements of the Pyrazole Moiety of Rimonabant: Synthesis, Biological Properties, and Molecular Modeling Investigations of Thiazoles, Triazoles, and Imidazoles as Potent and Selective CB1 Cannabinoid Receptor Antagonists.
  J. Med. Chem. 2005, 48, 1823-1838.
• α-Cycloalkyl-substituted ω-Keto-dicarboxylic Acids as Lipid Regulating Agents.
  Bioorg. Med. Chem. 2005, 13, 223-236.
• Facile Preparation of the Water-Soluble Singlet Oxygen Traps Anthracene-9,10-divinylsulfonate (AVS) and Anthracene-9,10-diethylsulfonate (AES) via a Heck Reaction with Vinylsulfonate.
  Synlett, 2005, 17, 2667-2669.
• Long Hydrocarbon Chain Diols and Diacids with Central Ether or Ketone Moieties that Favorably Alter Lipid Disorders.
  Pharmazie, 2006, 61, 157-165.
• Determination of Polar 1H-benzotriazoles and Benzothiazoles in Water by Solid-phase Extraction and Liquid Chromatography LTQ FT Orbitrap Mass Spectrometry.
  Int. J. Mass Spectr. 2009, 282, 99–107.
• A Novel Route to 2,4-Dianilino-substituted Pyrimidines.
  Tetrahedron Lett. 2010, 51, 543-544.
• 3-(Arylamino)-1,2,4-triazine-5-one: A Novel Synthesis and its Use.
  Eur. J. Org. Chem. 2010, 15, 2852-2854.
• 6-Phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile as Cathepsin S Inhibitors.
  Bioorg. Med. Chem. Lett. 2010, 20, 4350–4354.
• Design, Synthesis, Biological Properties, and Molecular Modeling Investigations of Novel Tacrine Derivatives with a Combination of Acetylcholinesterase Inhibition and Cannabinoid CB1 Receptor Antagonism.
  J. Med. Chem. 2010, 53, 1338–1346.
• Design, Synthesis, Biological Properties, and Molecular Modeling Investigations of Novel Tacrine Derivatives with a Combination of Acetylcholinesterase Inhibition and Cannabinoid CB1 Receptor Antagonism.
  J. Med. Chem. 2010, 53, 1338–1346.
• A Novel Procedure for the Coupling of Sterically-hindered Electron-deficient Anilines to the 6-Position of the Purine Core.
  Accepted for publication in Synth. Comm. 2011.

Posters